Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.

Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.

Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage.

Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.

Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10.

CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system.

Protein kinase C theta is expressed in mast cells and is functionally involved in Fcepsilon receptor I signaling.

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.

Vav2 is required for cell spreading.

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.

BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.

Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation.

Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.

A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation.

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.

Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.

Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors.

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.

Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain.

Src-family kinases in B-cell development and signaling.

ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner.

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.

Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity.

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.

Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells.

Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).

Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.

Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.

Leupaxin negatively regulates B cell receptor signaling.

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen.

Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.

Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.

Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase.

Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity.

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain.

The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association.

SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.

Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.

Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer.

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.

Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.

Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells.

Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis.

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.

Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma.

De Novo Gain-Of-Function Variations in LYN Associated With an Early-Onset Systemic Autoinflammatory Disorder.

Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome.

TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk.

Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.

G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes.

Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.

Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line.

Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.

Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen

Fyn/Lyn-mediated phosphorylation of FcR1 gamma

Lyn activates ERK

Binding of Syk tyrosine kinase

Phosphorylation of JAK2

GRB2 is indirectly recruited to p-KIT through SHP2

JAK2 binds to p-KIT

Phosphorylation of GAB2 by SFKs

Recruitment of STATs

Phosphorylation of SHP2 by SFKs

Phosphorylation of APS

Synthesis of PIP3 from PIP2 by PI3K

Phosphorylation and activation of VAV1

Phosphorylation of STATs

Dimerization of STATs

Disassociation and translocation of STATs to the nucleus

Phosphorylation of p-KIT on Y900 by Src kinases

Indirect recruitment of PI3K to KIT via p(Y)-GAB2

Cell surface interactions at the vascular wall

Sequestering and phosphorylation Fc gamma receptors in the lipid rafts

Fcgamma receptor (FCGR) dependent phagocytosis

Indirect recruitment of GAB2 to p-KIT

SHP2 interacts with p-KIT

Recruitment of CBL to KIT

Interaction of APS and p-KIT

Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src

Fc epsilon receptor (FCERI) signaling

Phosphorylation of beta and gamma subunits by LYN

Recruitment of SYK to p-FCERI gamma subunit

EPH-Ephrin signaling

Phosphorylation of TEC kinases by p-SYK

Phosphorylation of LAT by p-SYK

Phosphorylation of SLP-76 by p-SYK

Autophosphorylation of LYN kinase

Phosphorylation of PKC-theta

Phosphorylation of NTAL by p-SYK/Lyn

Phosphorylation of SHC by SYK kinase

SHP2 phosphatase binds CTLA-4

Phosphorylation of CD28

Phosphorylation of CTLA-4

Regulation of T cell activation by CD28 family

Co-stimulation by CD28

SFKs phosphorylate VAV2,3

p-EPHs bind VAV2,3

EPHB phosphorylates TIAM1

VAV exchanges GTP for GDP on RAC1, activating it

TIAM1 exchanges GTP for GDP on RAC1, activating it

EPHB:NMDAR binds TIAM1

NGEF exchanges GTP for GDP on RHOA

EPHA binds TIAM1

p-TIAM1 exchanges GTP for GDP on RAC1, activating it

GPVI binds Fyn and Lyn

GPVI stimulates PI3K beta, gamma

p-Y348-SYK dissociates

SYK autophosphorylates

LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG

C-type lectin receptors (CLRs)

SFKs phosphorylates RAF1 on Y340,Y341

LYN phosphorylates CD22

EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K

EPOR-associated PI3K phosphorylates PIP2 to PIP3

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2

JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1

Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK

Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers

FCGR3A-mediated IL10 synthesis

FCGR3A-mediated phagocytosis

Phosphorylation of STATs downstream of KIT mutants

JAK2 binds to p-KIT mutants

KIT mutants bind SFKs

Recruitment of STATs by KIT mutants

Dimerization of STATs downstream of KIT mutants

Phosphorylation of JAK2 downstream of KIT mutants

Disassociation and translocation of STATs to the nucleus downstream of KIT mutants

p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS

CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN

CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7

CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane

EPOR binds EPOR agonists

Growth hormone receptor signaling