TreeGrafter-generated GO annotations
Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.
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Mouse BICDR-1 is a Rab6 effector that recruits dynein/dynactin and Kif1C to Rab6/NPY secretory vesicles and keeps them in the pericentrosomal region.
"BICDR-1 interacts with Rab6, Kif1C and the dynein/dynactin motor complex, and coordinates trafficking of Rab6/NPY-positive secretory vesicles."
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Kif1C binds the N-terminal region of BICDR-1.
"Both full-length BICDR-1 and an N-terminal region of BICDR-1, amino acids 1–353, interact with the C-terminal tail domain of Kif1C"
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
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BICDR1 preferentially recruits two dyneins to dynactin, which produces faster movement than with BICD2.
"We conclude the majority of motile complexes containing BICD2 have one dynein, whereas both BICDR1 and HOOK3 preferentially recruit two."
UniProt record for donkey BICDL1 (A0A9L0JLY3)
UniProt Swiss-Prot record for human BICDL1 (Q6ZP65)
BICDL1: donkey-human sequence comparison
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Donkey and human BICDL1 are 96% identical over 524 aligned residues. Each has a segment of about 48 residues that has no counterpart in the other.
"The donkey sequence A0A9L0JLY3 (573 residues) aligns to human Q6ZP65 (573 residues) with 95.99% identity across 524 paired residues."
BICDL1 donkey gene-model comparison (re-review)
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The benchmark product is a non-canonical transcript of donkey BICDL1. It is the only donkey model that lacks the central coiled-coil segment found in the human and mouse canonical sequences.
"The benchmark product is the only donkey model that lacks SEG_CORE."