Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing.
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Transaldolase-deficient human lymphoblasts (Ser171 deletion) accumulate sedoheptulose 7-phosphate and are depleted of glucose 6-phosphate, demonstrating the enzyme's role in the non-oxidative pentose phosphate pathway.
"Sedoheptulose 7-phosphate was accumulated, whereas G6P (glucose 6-phosphate) was depleted"
Replacement of a phenylalanine by a tyrosine in the active site confers fructose-6-phosphate aldolase activity to the transaldolase of Escherichia coli and human origin.
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Human transaldolase (Taldo1) was biochemically assayed; the study confirms its transaldolase/aldolase activity and active-site mechanism.
"we show that a homologous replacement has a similar effect in the human transaldolase Taldo1 (aldolase activity, 14 units/mg)."
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Proteomic characterization of the human sperm nucleus.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression.
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Transaldolase is a key enzyme of the reversible non-oxidative branch of the pentose phosphate pathway, whose expression level modulates the balance between the oxidative and non-oxidative branches and thereby NADPH/GSH levels.
"Transaldolase (TAL) is a key enzyme of the reversible nonoxidative branch of the pentose phosphate pathway (PPP)"
Cloning and chromosomal localization of a paralog and a mouse homolog of the human transaldolase gene.
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P
Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate
Expression of transaldolase 1
NFE2L2-dependent TALDO1 gene expression
UniProtKB entry P37837 (TALDO_HUMAN), transaldolase