Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas.
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SVH splice variants localize to the ER.
"Four variants of SVH, SVH-A, -B, -C, and -D, resulting from alternative splicing in the coding region of the SVH transcript, were observed and were all localized in endoplasmic reticulum (ER)."
APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest.
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APEX labelling resolves sub-mitochondrial localization.
"Using APEX labeling of specific proteins, we uncovered subcellular localization at sub-compartmental resolution and successfully elucidated the membrane protein topology of HMOX1 and sub-mitochondrial localization of recently identified mitochondrial proteins."
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
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High-confidence human mitochondrial proteome.
"We classified >8,000 proteins in mitochondrial preparations of human cells and defined a mitochondrial high-confidence proteome of >1,100 proteins (MitoCoP)."
Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics.
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AMPK phosphorylates ARMC10 S45; ARMC10 is required for AMPK-induced fission.
"Moreover, ARMC10 overexpression was sufficient to promote mitochondrial fission, whereas ARMC10 knockout prevented AMPK-mediated mitochondrial fission."
The Armc10/SVH gene: genome context, regulation of mitochondrial dynamics and protection against Aβ-induced mitochondrial fragmentation.
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Armc10 regulates mitochondrial trafficking and co-immunoprecipitates with Miro1/2 and Trak2.
"Co-immunoprecipitation experiments in HEK293T cells transfected with Armc10-GFP and either Miro1-myc or Miro2-myc cDNAs revealed that Miro proteins were detected by WB in lysates immunoprecipitated with anti-GFP antibodies."
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons.
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Mouse ArmC10 is a high-affinity oncomodulin receptor.
"Using proximity biotinylation, coimmunoprecipitation, surface plasmon resonance, and ectopic expression, we have identified armadillo-repeat protein C10 (ArmC10) as a high-affinity receptor for Ocm."
SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.
UniProt entry Q8N2F6 (ARM10_HUMAN)
Affinage mechanistic annotation for ARMC10 (human)