Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Human Ig superfamily CTLA-4 gene chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains.
Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.
Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation.
Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.
Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells.
A molecular perspective of CTLA-4 function.
ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia.
CTLA-4 trafficking and surface expression.
Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.
A secreted protein microarray platform for extracellular protein interaction discovery.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.
Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
A reference map of the human binary protein interactome.
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A physical wiring diagram for the human immune system.
Multimodal cell maps as a foundation for structural and functional genomics.
SHP2 phosphatase binds CTLA-4
Phosphorylation of CTLA-4
CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1
Deep research report on CTLA4 function, trafficking, and clinical applications.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Role of CTLA4 in the proliferation and survival of chronic lymphocytic leukemia.
The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
CTLA-4 is important in maintaining long-term survival of cardiac allografts.