Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships.
Proteomic analysis of the Drosophila larval hemolymph clot.
The serine protease Sp7 is expressed in blood cells and regulates the melanization reaction in Drosophila.
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Sp7 RNAi impairs melanization upon injury and blocks phenoloxidase activation; Sp7 is expressed in blood cells (crystal cells).
"Our data demonstrate that Sp7 is required for phenoloxidase activation and its activity is restricted to a subclass of blood cells, the crystal cells."
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila.
Two proteases defining a melanization cascade in the immune system of Drosophila.
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MP2 (Sp7) acts in a Spn27A-regulated melanization cascade, mainly during fungal infection.
"MP1 is required to activate melanization in response to both bacterial and fungal infection, whereas MP2 is mainly involved during fungal infection."
Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger.
A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections.
Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts.
Serine protease MP2 activates prophenoloxidase in the melanization immune response of Drosophila melanogaster.
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Activated recombinant MP2 (Sp7) has amidase activity, cleaves recombinant and native PPO1, and is inhibited by Spn27A.
"MP2 functions as a prophenoloxidase-activating protease, and that this function is inhibited by Spn27A"
Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects.
More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila.
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Sp7 controls an alternate melanization that clears S. aureus, downstream of ModSP and Grass.
"Sp7 regulates an alternate melanization reaction responsible for the clearance of Staphylococcus aureus"
UniProtKB/Swiss-Prot entry Q9V3Z2 (SER7_DROME)