ROR2 (human, Q01974) curation notes

Deep research providers were unavailable in this environment; evidence is from cached publications
and UniProt.

Localization

• Single-pass type I plasma membrane receptor: UniProt SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein; extracellular Ig-like, Frizzled-like
  cysteine-rich and kringle domains are surface-exposed.
• PMID:17717073 — cell-surface accessible, confirmed by
  bivalent-antibody-induced dimerization (relevant for antibody-based targeting).
• Clathrin-coated endocytic vesicle membrane (Reactome) kept as non-core trafficking compartment.

Kinase activity

• PMID:17717073; UniProt EC 2.7.10.1. UniProt also notes "has also been shown
  to have very little tyrosine kinase activity in vitro", and TAK1-dependent phosphorylation of ROR2
  is "not mediated by the Ror2 tyrosine kinase domain" PMID:18762249. The kinase rows were
  therefore ACCEPTed (not removed as for a true pseudokinase such as PTK7) but the weak-activity
  caveat is recorded here and in the description.

Wnt function

• UniProt: "May act as a receptor for wnt ligand WNT5A which may result in the inhibition of
  WNT3A-mediated signaling"; WNT5B identified in osteosarcoma PMID:19486338.
• ROR2 knockdown reduces osteosarcoma proliferation and migration PMID:19486338.

Review decisions

• 29 generic GO:0005515 rows removed per policy; Wnt-protein binding and MAP3K binding kept.
• GO:0004672 protein kinase activity modified to the tyrosine-specific terms; GO:0007165 signal transduction modified to the RTK signalling pathway term.
• GO:0030424 axon (IBA) kept as non-core.