Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.
Atg101, a novel mammalian autophagy protein interacting with Atg13.
Nix, a receptor protein for mitophagy in mammals.
Network organization of the human autophagy system.
ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy.
A directed protein interaction network for investigating intracellular signal transduction.
FIP200 regulates targeting of Atg16L1 to the isolation membrane.
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.
Huntingtin functions as a scaffold for selective macroautophagy.
Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.
The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.
The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Regulation of autophagosome biogenesis by OFD1-mediated selective autophagy.
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.
The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Global Proximity Interactome of the Human Macroautophagy Pathway.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex.
ULK1 phosphorylates AMBRA1:BECN1 complex
AMPK (complex) phosphorylates ULK1 (complex)
Thr-180 of ULK1 is phosphorylated
Active MTORC1 phosphorylates ULK1
p-AMPK:AMP binds the ULK complex
Active MTORC1 binds the ULK1 complex
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
MTORC1 dissociates from ULK complex
ULK1 phosphorylates ATG13 and RB1CC1
ULK1 phosphorylates Beclin-1
ULK complex translocates to the ER