Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Variants in ASB10 are associated with open-angle glaucoma.
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ASB10 is cytoplasmic and nuclear in eye tissues; silencing reduces outflow facility.
"In the ciliary body, ASB10 was mainly observed in the cytoplasm and perinuclear region of pigmented ciliary epithelial cells covering the ciliary processes, with minimal expression in non-pigmented epithelial cells (Fig."
A reference map of the human binary protein interactome.
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
CAND1 binds cytosolic CRL E3 ubiquitin ligases
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer.
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ASB10 ubiquitylates TEM8 for degradation.
"ASB10, an estrogen receptor ERα trans-activated E3 ligase, ubiquitylates TEM8 for degradation, and its deficiency in TNBC resulted in a high homeostatic level of TEM8."
Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells.
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ASB10 co-immunoprecipitates HSP70 and the 20S proteasome alpha4 subunit in trabecular meshwork cells.
"Coimmunoprecipitation assays showed a positive interaction of ASB10 with HSP70 and with the α4 subunit of the 20S proteasome."
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ASB10 is on autophagy-lysosome pathway vesicles.
"ASB10 also colocalized with numerous biomarkers of specific autophagic structures: aggresomes (histone deacetylase 6 [HDAC6] and heat shock protein 70 [HSP70]), autophagosomes (light chain 3 [LC3] and p62), amphisomes (Rab7), and lysosomes (lysosomal-associated membrane protein 1 [LAMP1])."
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
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Asb10 stabilizes HSP70 by competitively inhibiting STUB1-mediated degradation, exacerbating cardiac hypertrophy.
"Collectively, these findings demonstrate that Asb10 stabilizes HSP70 via competitively inhibiting STUB1-mediated ubiquitin-dependent degradation, thereby exacerbating cardiac hypertrophy, highlighting the role of Asb10 in hemodynamic stress-induced cardiac hypertrophy and heart failure."
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
UniProt entry Q8WXI3 (ASB10_HUMAN)
Affinage mechanistic annotation for ASB10 (human)
Reactome R-HSA-8952039: NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
Reactome R-HSA-8952044: AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
Reactome R-HSA-8955241: CAND1 binds cytosolic CRL E3 ubiquitin ligases
Reactome R-HSA-8955289: COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
Reactome R-HSA-8956040: COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes