Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Noxa in colorectal cancer: a study on DNA, mRNA and protein expression.

The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death.

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha.

BOK and NOXA are essential mediators of p53-dependent apoptosis.

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection.

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Functional linkage between NOXA and Bim in mitochondrial apoptotic events.

CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.

Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death.

Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines.

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose.

Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells.

Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis.

The unfolded protein response: integrating stress signals through the stress sensor IRE1α.

Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

TP53 stimulates PMAIP1 (NOXA) expression

Translocation of PMAIP1 (NOXA) to mitochondria

Transactivation of PMAIP1 (NOXA) by E2F1

BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

Structural insights into the degradation of Mcl-1 induced by BH3 domains.