Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal.
Short interfering RNA against the PDCD5 attenuates cell apoptosis and caspase-3 activity induced by Bax overexpression.
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.
Studies on interactions of programmed cell death 5 (PDCD5) and its related peptides with heparin by capillary zone electrophoresis.
PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis.
-
PDCD5 binds and stabilizes Tip60
-
PDCD5 enhances Tip60 HAT activity
-
PDCD5 promotes p53 K120 acetylation via Tip60
-
Nuclear localization after DNA damage
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway.
-
PDCD5 directly binds p53
-
PDCD5 antagonizes MDM2-mediated p53 degradation
-
PDCD5 promotes p53 phosphorylation
-
ChIP shows PDCD5 at p21 promoter
PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+) regulatory T cells and suppressing Th17 and Th1 responses.
-
PDCD5 interacts with FOXP3
-
PDCD5 enhances FOXP3 acetylation with Tip60
-
PDCD5 promotes Treg differentiation
-
TGF-beta sensitivity enhanced in PDCD5 transgenic mice
Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding.
-
PDCD5 binds CCT chaperonin
-
PDCD5 inhibits beta-tubulin folding
-
Cryo-EM structure of PDCD5-CCT complex
Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5.
-
PPEF-1 dephosphorylates PDCD5 at Ser-119
-
Phosphorylation promotes nuclear localization
-
CK2 phosphorylates, PPEF-1 dephosphorylates
A reference map of the human binary protein interactome.