Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells.

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis.

Dynamin-like protein 1 is involved in peroxisomal fission.

The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11.

The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1.

A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.

Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis.

The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells.

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission.

SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle.

Defining the membrane proteome of NK cells.

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms.

Dynamin-like protein 1 at the Golgi complex: a novel component of the sorting/targeting machinery en route to the plasma membrane.

Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization.

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells.

RAC3 is a pro-migratory co-activator of ERα.

MiD49 and MiD51, new components of the mitochondrial fission machinery.

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission.

RALA and RALBP1 regulate mitochondrial fission at mitosis.

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage.

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.

An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2.

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation.

Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.

Functional mapping of human dynamin-1-like GTPase domain based on x-ray structure analyses.

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.

Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics.

Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins.

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.

COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1.

Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes.

Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function.

SAMM50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells.

A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.

FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.

DNM1L-related encephalopathy in infancy with Leigh syndrome-like phenotype and suppression-burst.

Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.

Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis.

Mutations in DNM1L, as in OPA1, result in dominant optic atrophy despite opposite effects on mitochondrial fusion and fission.

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance.

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease.

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.

PINK1 phosphorylates Drp1(S616) to regulate mitophagy-independent mitochondrial dynamics.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation.

Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p.

Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells.

A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells.

Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase Vps1p.

Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.

Mitochondrial recruitment of Drp1

Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization.

Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease.

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.

PEX14 is required for microtubule-based peroxisome motility in human cells.

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.

A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.

Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules.

A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane.

Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission.

GTPBP8 modulates mitochondrial fission through a Drp1-dependent process.

Subcellular localization of DNM1L - The Human Protein Atlas