Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
RGD ISO annotations to rat from other mammalian species
Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.
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Endogenous DSP21 in rat testis is a peripheral inner-membrane protein facing the mitochondrial matrix.
"collectively these data suggest that DSP21 is localized to mitochondria in testis tissue where it peripherally associates with the IM within the matrix compartment"
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Recombinant DSP21 is a catalytically active phosphatase dependent on its active-site cysteine.
"Mutation of the catalytic active site cysteine to serine abolished phosphatase activity of both DSP18 and DSP21"
Identification and characterization of two novel low-molecular-weight dual specificity phosphatases.
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Human DUSP21 dephosphorylates pTyr and pThr MAPK peptides in vitro, preferring pTyr.
"In vitro experiments also demonstrate that both DSPs can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine."
Dual-specific phosphatase DUSP21 is a novel negative feedback regulator for STAT3.
RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma.
Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility.
In-cell structural insight into the stability of sperm microtubule doublet.
Doublet microtubule-associated tektins and enzymes differentially regulate sperm flagellar integrity and motility.
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Dusp21 knockout spermatozoa have normal morphology, motility and fertility.
"In contrast, Dusp21-/y spermatozoa exhibited normal morphology, motility, and fertility, mirroring WT phenotypes"
UniProtKB D3ZAQ8 (rat Dusp21) flat file