Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:16262699

Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.

Human hDPS1 (PDSS1) and hDLP1 (PDSS2) form a heterotetrameric decaprenyl diphosphate synthase; reconstitution in E. coli verifies in vitro decaprenyl diphosphate synthase activity and Q10 production, and both subunits contribute to determining the ubiquinone side chain.

"murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (mSPS1) and hDLP1 (mDLP1)"

PMID:34800366

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

High-confidence quantitative human mitochondrial proteome; the experimental basis for the UniProt mitochondrial subcellular-location call for PDSS1.

Reactome:R-HSA-2162253

PDSS1,2 ligates FPP to IPPP

Reactome reaction: the PDSS1/PDSS2 tetramer condenses (2E,6E)-farnesyl diphosphate with seven isopentenyl diphosphate to form all-trans-decaprenyl diphosphate in the mitochondrial matrix.