Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
UniProt entry A0A314LBC4 for Nicotiana attenuata FOX2_2
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FOX2_2 is a BBL-family nicotine-associated oxidoreductase
"Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine ... Catalyzes a late oxidation step subsequent to the pyridine ring condensation reaction in the biosynthesis of alkaloids."
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UniProt places FOX2_2 in vacuole
"CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000256|ARBA:ARBA00004116}."
NaBBL FOX2_2 candidate notes
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BBL-family late-pathway chemistry is supported for FOX2_2-class paralogs
"The full preprint places a BBL-family enzyme directly in the nicotine synthase cascade as NicGS, with structural support and clear effects on stereoselective product formation."
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FOX2_2 remains unresolved at the specific NICAT paralog level
"FOX2_2 therefore remains a plausible BBL-family paralog to evaluate, but the paper still leaves the exact NICAT paralog mapping unresolved."