atg-2 (Q21480) review notes

Deep research: falcon attempt timed out on 2026-10-08 and perplexity was unavailable; no
deep-research file. Review based on cached papers, UniProt and PubMed.

Key facts

• ATG2-family bridge-like lipid transfer protein (2290 aa). Lipid transfer is shown for orthologs [PMID:30952800 "ATG2A can bind tens of glycerophospholipids at once and transfers lipids robustly in vitro"; PMID:30911189 "Atg2 acts as a lipid-transfer protein that supplies phospholipids for autophagosome formation"].
• Binds EPG-6 directly; the ATG-2/EPG-6 complex acts at omegasome-to-autophagosome progression PMID:21802374.
• Acts upstream of MTM-3 and EPG-5 PMID:25124690.
• Acts cell-autonomously in AIY neurons for presynaptic assembly PMID:27396362.

Decisions

• IMP positive regulation of autophagy (PMID:25124690) modified to autophagosome assembly: ATG-2 is core machinery, not a regulator.
• PMN IBA marked over-annotated (yeast-specific process).
• protein binding IPI removed (interaction real; captured as GO:0062079 complex membership, NEW).
• NEW: GO:0120013 lipid transfer activity (ISS from ATG2A/S. pombe Atg2), GO:0062079 ATG2-ATG18 complex.