TreeGrafter-generated GO annotations
The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis.
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Human ENTR1 (SDCCAG3) is an early/recycling endosomal protein that accumulates at the midbody during cytokinesis, complexes with PTPN13 and binds GIT1; its over- or under-expression increases multinucleation.
"SDCCAG3 is a novel endosomal protein, primarily localized at the early/recycling endosomal compartment"
Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.
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Human ENTR1 (SDCCAG3) associates with retromer indirectly, through the WASH complex, and this association is needed for its targeting to retromer-labelled endosomes.
"Together, these data establish that the association of ANKRD50, SDCCAG3, and RME-8 to retromer is mediated through binding to the WASH complex, and for SDCCAG3 this is necessary for targeting to retromer-labeled endosomes."
Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling.
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The VPS35 interactome includes SDCCAG3 (ENTR1); its depletion reduces GLUT1 surface levels, with only minor effects on other SNX27-retromer cargo.
"Suppression of SDCCAG3 led to a decrease in GLUT1 surface expression and a reduction in whole-cell levels, but this did not correlate with an obvious accumulation of GLUT1 in lysosomes"
The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis.
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The N-terminal 100 residues of human ENTR1 are necessary and sufficient for basal body localization and mediate IFT88 binding.
"Amino acids 1-100 of SDCCAG3 are necessary and sufficient for basal body localization"
UniProtKB Swiss-Prot record Q96C92 (human ENTR1), fetched 2026-10-14
ENTR1: donkey-human sequence comparison
ENTR1: PANTHER PTHR31259 subfamily placement (re-review)