Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Annotation inferences using protein family information
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase
Protein binding and signaling properties of RIN1 suggest a unique effector function
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.
Interaction between ATM protein and c-Abl in response to DNA damage.
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.
Regulation of Rad51 function by c-Abl in response to DNA damage
Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton.
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage.
Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.
Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress.
Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck.
Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.
The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19.
Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK.
Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene - a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks.
Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease.
c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide
Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases.
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution.
Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity.
c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.
Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
C-Abl as a modulator of p53.
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Physical and functional interaction between hMSH5 and c-Abl.
Characterization of p87C3G, a novel, truncated C3G isoform that is overexpressed in chronic myeloid leukemia and interacts with Bcr-Abl.
Abl kinase interacts with and phosphorylates vinexin.
MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage.
NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.
Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli.
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.
Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase.
Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1.
c-Abl kinase is required for beta 2 integrin-mediated neutrophil adhesion.
Evidence for a direct involvement of hMSH5 in promoting ionizing radiation induced apoptosis.
Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation.
c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response.
Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.
ABL tyrosine kinases - evolution of function, regulation, and specificity
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.
MutS homologue hMSH5 - role in cisplatin-induced DNA damage response.
Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
Tyrosine phosphorylation of a SNARE protein, syntaxin 17 - implications for membrane trafficking in the early secretory pathway.
Abl family kinases regulate endothelial barrier function in vitro and in mice.
Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin
Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease.
EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
The association of cortactin with profilin-1 is critical for smooth muscle contraction.
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells.
Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations.
Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.
Architecture of the human interactome defines protein communities and disease networks.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Structural and functional consequences of the STAT5B(N642H) driver mutation.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell - Endogenous tagging for the cartography of human cellular organization.
A central chaperone-like role for 14-3-3 proteins in human cells.
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
Systematic identification of post-transcriptional regulatory modules.
Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
Reactome - Fcgamma receptor (FCGR) dependent phagocytosis
Reactome - EPH-ephrin signaling
Reactome - Termination of O-glycan biosynthesis
Reactome - ESR-mediated signaling
Reactome - RUNX1 regulates transcription of genes involved in differentiation of HSCs
Reactome - ABL1 signaling events
Reactome - Fc-gamma receptor signaling
Reactome - ABL1 signaling in DNA damage response
Reactome - DNA damage checkpoint signaling
Reactome - Endothelial cell response to shear stress
Reactome - ABL1 cytosolic signaling
Reactome - ABL1 kinase activity
The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures.
Deep research summary for ABL1