Human BRWD3 depletion perturbs cell morphology in the PC3 screen, supporting a downstream cellular phenotype rather than a defined direct cytoskeletal activity.

The correction to the morphology-screen paper concerns ARC/ZRANB1 images and does not establish that the BRWD3 result was invalid.

Human BRWD3 bromodomain 2 was included in the primary histone-peptide array, but the inspected text does not establish a target-specific quantitative binding preference.

BRWD3 binds DDB1 and recruits it to active promoters in the studied mouse preadipocyte transcriptional program, through a mechanism separable from DDB1's CUL4 ligase role.

The fly family homolog acts as a CRL4-associated specificity factor in light-dependent cryptochrome ubiquitylation; this is not evidence that human BRWD3 uses the same substrate.

The fly family homolog restricts HIRA/YEM-mediated histone H3.3 deposition and associated transcriptional changes; the immediate molecular substrate remains unresolved in this study.

The erratum corrects an author name in PMID:25666827 without reporting a change to its biological results.

Drosophila BRWD3 promotes KDM5 K48-linked ubiquitylation and turnover and thereby influences H3K4 methylation. The paper does not establish that human BRWD3 or its paralogs degrades human KDM5.

Truncating BRWD3 variants segregate with X-linked intellectual disability and macrocephaly in the reported human families; phenotype evidence does not by itself identify a developmental molecular step.