Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
The alginate regulator AlgR and an associated sensor FimS are required for twitching motility in Pseudomonas aeruginosa.
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fimS (algZ, PA5262), adjacent to algR, is required for twitching motility.
"Adjacent to algR we have identified a sensor gene (fimS), which is also required for twitching motility."
The Pseudomonas aeruginosa AlgZR two-component system coordinates multiple phenotypes.
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AlgZ lacks the G1, F and G2 boxes of the ATP lid; only the H and N boxes are recognisable.
"The obvious similarities between AlgZ and canonical histidine kinases are limited to these two boxes, as AlgZ lacks identifiable G1, F, and G2 boxes that make up the ATP-coordinating flexible lid."
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AlgR phosphorylation (attributed to AlgZ) activates fimU transcription.
"Together, these data indicate that AlgR phosphorylation by AlgZ increased AlgR affinity to the fimU promoter and activated its transcription."
The Pseudomonas aeruginosa ribbon-helix-helix DNA-binding protein AlgZ (AmrZ) controls twitching motility and biogenesis of type IV pili.