Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Large-scale proteomics and phosphoproteomics of urinary exosomes.
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Urinary exosome proteome.
"Here, we used LC-MS/MS to profile the proteome of human urinary exosomes."
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.
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Armc3 loss blocks spermatid ribophagy and causes male infertility.
"Proteomic analysis indicated that the autophagic degradation of cytosolic ribosomes was blocked in ARMC3-deficient spermatids, which caused low energy levels of mitochondria and motionless flagella."
A conserved Vac8/ARMC3-PtdIns3K-CI cascade regulates autophagy initiation and functions in spermiogenesis by promoting ribophagy.
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Armc3-null spermatids show blocked ribophagy.
"Interestingly, spermatids from mice with Armc3 deletion showed blocked ribophagy, low energy levels of mitochondria and motionless flagella, which caused male infertility."
A homozygous ARMC3 splicing variant causes asthenozoospermia and flagellar disorganization in a consanguineous family.
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A homozygous ARMC3 splice variant causes asthenozoospermia.
"Individuals homozygous for the ARMC3 splicing variant displayed reduced sperm motility with frequent morphological abnormalities of sperm flagella."
A frameshift mutation in ARMC3 is associated with a tail stump sperm defect in Swedish Red (Bos taurus) cattle.
UniProt entry Q5W041 (ARMC3_HUMAN)
Affinage mechanistic annotation for ARMC3 (human)