Gene Ontology annotation through association of InterPro records with GO terms
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PGRPS2 has InterPro domains including IPR002502 (Amidase_domain), IPR006619 (PGRP domain), IPR017331 (Peptidoglycan_recognition), and IPR015510 (PGRP)
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Combined Automated Annotation using Multiple IEA Methods
Molecular evolution of the three short PGRPs of the malaria vectors Anopheles gambiae and Anopheles arabiensis in East Africa
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Seven PGRP genes are known in the Anopheles gambiae genome, including three short PGRPs (S1, S2, S3)
"Seven PGRP genes are known in the Anopheles gambiae genome"
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PGRPS2 and PGRPS3 have predicted amidase activity while PGRPS1 does not
"Short-PGRP genes from An. gambiae differ in their structure, as PGRP-S2 and S3 have predicted amidase activity while PGRP-S1 does not"
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PGRPS2 is under purifying selection suggesting functional constraint
"The two short PGRP genes located in the chromosome-2L were under purifying selection, which suggests functional constraints"
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Short PGRPs are secreted extracellular proteins present in hemolymph
"In Drosophila short PGRPs are small extracellular proteins about 200 amino acids long and 18-20 kDa that are present in the hemolymph and cuticle"
PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction
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Amidase PGRPs cleave PGN into non-immunogenic compounds
"Amidase PGRPs are capable of cleaving the PGN into non-immunogenic compounds"
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Zn2+ is coordinated by two histidines and one cysteine in catalytic PGRPs
"The main difference between amidase and non-catalytic PGRPs is the presence of Zn2+ in only amidase PGRPs, which is coordinated by two histidines and one cysteine"
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Conserved H42, H152, Y78, C160 coordinate Zn2+ in catalytic site
"reveal the highly conserved residues of Drosophila PGRP-LBPA/PC histidine 42 (H42), histidine 152 (H152), tyrosine 78 (Y78) and cysteine 160 (C160) in coordination with Zn2+ in the catalytic site"
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PGRP-LB downregulates the IMD pathway by cleaving DAP-type PGN
"Drosophila PGRP-LB belongs to the amidase PGRPs and downregulates the immune deficiency (IMD) pathway by cleaving meso-2,6-diaminopimelic (meso-DAP or DAP)-type PGN"
Deep research summary for PGRPS2
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Literature review confirms PGRPS2 is a secreted short PGRP with conserved catalytic residues
"PGRP-S2 (UniProt D2SU82; also PGRPS2, PGRP-S2) is one of three short, secreted PGRPs (S1, S2, S3) in this species"