Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator.

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.

Cyclin E in normal and neoplastic cell cycles.

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.

The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells.

Regulation of the transcription factor FOXM1c by Cyclin E/CDK2.

G1/S Cyclins interact with regulatory subunit of PKA via A-kinase anchoring protein, AKAP95.

Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis.

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.

p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.

Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia.

HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression.

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.

Toward an understanding of the protein interaction network of the human liver.

miR-16 inhibits the proliferation and angiogenesis-regulating potential of mesenchymal stem cells in severe pre-eclampsia.

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

The protein interaction landscape of the human CMGC kinase group.

Foxp3 protein stability is regulated by cyclin-dependent kinase 2.

Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

MicroRNA-30c-2-3p negatively regulates NF-κB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer.

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

Architecture of the human interactome defines protein communities and disease networks.

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

A protein interaction landscape of breast cancer.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

Multimodal cell maps as a foundation for structural and functional genomics.

Alternative splicing of human cyclin E.

Human papillomavirus E7 oncoproteins bind a single form of cyclin E in a complex with cdk2 and p107.

Cyclin-binding motifs are essential for the function of p21CIP1.

Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.

Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.

Translocation of Cyclin E:Cdk2 complex to the nucleus

Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21

Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Degradation of ubiquitinated p27/p21 by the 26S proteasome

Ubiquitination of phospho-p27/p21

CAK-mediated phosphorylation of Cyclin E:Cdk2

Association of Rb with Cyclin E:Cdk2 complexes

Cyclin E:CDK2-mediated phosphorylation of RB1

Cdc6 protein is phosphorylated by CDK

Formation of Cyclin E:Cdk2 complexes

Phosphorylation of Cyclin E:CDK2 complexes by WEE1

Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A

CCNE1 gene transcription is stimulated by E2F1

RHOBTB3 binds interacting proteins at trans-Golgi network