Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?
Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus.
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.
Sticking together and sorting things out: adhesion as a force in development.
Hedgehog acts as a somatic stem cell factor in the Drosophila ovary.
A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog.
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.
Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2.
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction.
Extensive phosphorylation of Smoothened in Hedgehog pathway activation.
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.
Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.
BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.
Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb.
Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms.
Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.
The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway.
A large complex containing Patched and Smoothened initiates Hedgehog signaling in Drosophila.
Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused.
Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.
Hedgehog regulates smoothened activity by inducing a conformational switch.
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
Regulation of smoothened by Drosophila G-protein-coupled receptor kinases.
Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling.
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila.
Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses.
Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.
Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling.
The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.
USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization.
Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.
Distinct phosphorylations on kinesin costal-2 mediate differential hedgehog signaling strength.
Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner.
Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila.
Cilia-mediated hedgehog signaling in Drosophila.
Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation.
Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.
Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator.
Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes.
A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.
PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.
Dose-dependent transduction of Hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor Smoothened and the kinase Fused.
Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in the Drosophila ovary.
Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.
Protein association changes in the Hedgehog signaling complex mediate differential signaling strength.
Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.
The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth.
Dissection of the microRNA Network Regulating Hedgehog Signaling in Drosophila.
High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened.
Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development.
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.
Dual roles for patched in sequestering and transducing Hedgehog.
Phosphorylation of SMO by CKIalpha
Liberation of CI from SU(FU) repression
Autophosphorylated FU phosphorylates COS
Phosphorylation of SMO by PKA-C1
Dissociation of CI from COS
Phosphorylated SMO changes conformation and is activated
UniProt record for Drosophila smo
FlyBase gene description for smo (DROME)