Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Combined Automated Annotation using Multiple IEA Methods

Human methionine synthase reductase is a molecular chaperone for human methionine synthase.

Crystal structure and solution characterization of the activation domain of human methionine synthase.

Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia.

Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC.

Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.

Methylation

Sulfur amino acid metabolism

MTR transfers CH3 from MeCbl to HCYS

MTRR reduces cob(II)alamin to meCbl

MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin

cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR

Defective MTRR does not convert cob(II)alamin to MeCbl

Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin

Defective MTR does not transfer CH3 group from MeCbl to HCYS

Cobalamin (Cbl) metabolism