Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:EQUAS/LOXL3/LOXL3-uniprot.txt

UniProt record for donkey LOXL3 (A0A9L0K7N3)

file:EQUAS/LOXL3/LOXL3-bioinformatics/RESULTS.md

LOXL3: donkey-human sequence comparison

Catalytic copper-binding and LTQ residues are conserved in donkey LOXL3.

"the lysine tyrosylquinone (LTQ) cofactor residues (human Lys634 and Tyr670 = donkey Lys705 and Tyr741) are conserved"

PMID:11284725

Cloning and characterization of a fourth human lysyl oxidase isoenzyme.

PMID:17018530

A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity.

PMID:28065600

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.

PMID:26954549

Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion.

Mouse Loxl3 is secreted from myofiber termini and directly oxidizes fibronectin at the myotendinous junction.

"We find that LoxL3 complexes with and directly oxidizes Fibronectin (FN)"

PMID:26307084

Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice.

Loxl3-null mice have reduced collagen cross-links in palate and spine.

"We found that the obvious decrease of collagen cross-links in palate and spine that was induced by the lack of LOXL3 resulted in cleft palate and spinal deformity."

file:EQUAS/LOXL3/LOXL3-bioinformatics/RESULTS-rereview.md

LOXL3 (donkey A0A9L0K7N3): re-review sequence and phylogenetic placement

The donkey gene model carries a 52-aa N-terminal extension and a 19-aa SRCR2 insertion absent from the otherwise identical horse protein.

"Donkey A0A9L0K7N3 (824 aa) is identical to horse A0A9L0TKN1 (753 aa) at all 753 aligned positions."
Donkey LOXL3 is in the LOXL3 PANTHER subfamily with human and mouse LOXL3.

"UniProt places donkey A0A9L0K7N3 in PANTHER PTHR45817:SF2 (LYSYL OXIDASE HOMOLOG 3)"

PMID:28112368

LOXL3-sv2, a novel variant of human lysyl oxidase-like 3 (LOXL3), functions as an amine oxidase.