Rtl8a notes

Mouse Rtl8a/Rtl8b encode identical 113-aa capsid-only proteins; rodent-specific N-terminal NLS; nuclear(nucleoli), and nucleus+cytoplasm in PFC neurons [PMID:39875098 "the former in the nuclei (nucleoli) and the latter in the cytoplasm"; "these proteins are localized in both the nucleus (indicated by arrows) and cytoplasm of neurons"]. Rtl8a/8b DKO: late-onset obesity, reduced social response, apathy, reduced GABRB2 PMID:39875098. No GOA annotations -> NEW only.
Conserved adaptor role from human RTL8-UBQLN2/PEG10 [PMID:40680123; PMID:35247097].
NEW: nucleus (IDA), protein-macromolecule adaptor activity (ISS), positive regulation of protein localization to nucleus (ISS).

Deep research integration (OpenScientist, 2026-10-24)

Report read as leads and checked against cached sources.

• Contradiction: the report says endogenous mouse Rtl8a loss-of-function phenotypes "are not yet well characterized in the retrieved literature". The Rtl8a/8b double-knockout study PMID:39875098 already characterizes late-onset obesity, reduced social response and apathy-like behaviour; the report missed it. The review is unchanged on this point.
• Verified and added: the UBQLN2-RTL8 interaction was confirmed in mouse brain PMID:35247097, added to the adaptor activity row. RTL8 is incorporated into PEG10 VLPs and lowers their abundance PMID:39775359, added to the core function description and support. Note that 39775359 used human RTL8C.
• Nucleolar localization: human RTL8 "Under endogenous and overexpressed conditions, RTL8 localizes to nucleoli." PMID:35247097; the mouse paper says "in the nuclei (nucleoli)" PMID:39875098. The nucleus NEW row was kept rather than narrowed to nucleolus, because in prefrontal-cortex neurons the mouse signal is nuclear plus cytoplasmic without a nucleolar call; nucleolus (GO:0005730) is a reasonable future refinement.
• Stress-granule recruitment of UBQLN2 by PEG10 requires RTL8 PMID:40680123; no stress-granule location asserted for RTL8 itself.
• The report's paralog-collective caveat (assays detect "RTL8" collectively) is quoted as support for the existing knowledge gap.

No action changes.