Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Towards a proteome-scale map of the human protein-protein interaction network.

The glycine cleavage system: structure of a cDNA encoding human H-protein, and partial characterization of its gene in patients with hyperglycinemias.

A reference map of the human binary protein interactome.

Cloning of cDNA encoding human H-protein, a constituent of the glycine cleavage system.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Pathogenic variants in GCSH encoding the moonlighting H-protein cause combined nonketotic hyperglycinemia and lipoate deficiency.

PXLP-K754-GLDC dimer decarboxylates Gly

AMT transfers NH2CH2 from GCSH:SAMDLL to THF

DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate

LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST

LIPT2 transfers octanoyl group to GCSH

LIAS synthesizes lipoyl-GCSH

LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT

UniProtKB P23434 (GCSH_HUMAN) entry