MET6 notes (YER091C, P05694)

• Cobalamin-independent methionine synthase (MetE), EC 2.1.1.14, Zn-dependent [UniProt:P05694 "Reaction=5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine ="]; [UniProt:P05694 "SIMILARITY: Belongs to the vitamin-B12 independent methionine synthase"].
• Cloned by complementation of met6 PMID:3542720.
• Zinc protein PMID:30358795
• Very abundant [UniProt:P05694 "Present with 264000 molecules/cell in log phase SD"].

Curation observations

• IBA GO:0008705 methionine synthase activity (EC 2.1.1.13 = MetH, monoglutamate) -> MODIFY to GO:0003871 (EC 2.1.1.14). Yeast lacks MetH.
• L-methionine salvage IEA (derived from GO:0008705 part_of) kept non-core; methionine cycle is the better description.
• Threonine metabolism RCA (P4-PWY-1) REMOVED; plasma membrane HDA over-annotated.