Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Combined Automated Annotation using Multiple IEA Methods

LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.

Triangular tibia with fibular aplasia associated with a microdeletion on 2q11.2 encompassing LAF4.

Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output.

Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex.

Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma.

A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron.

AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells.

Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy.

AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination.

FRA2A is a CGG repeat expansion associated with silencing of AFF3.

Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles.

A phenome-wide association study of methylated GC-rich repeats identifies a GCC repeat expansion in AFF3 associated with intellectual disability.

Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian.

Cloning and developmental expression of the murine homolog of the acute leukemia proto-oncogene AF4.

Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.

The little elongation complex regulates small nuclear RNA transcription.

De novo AFF3 variant in a patient with mesomelic dysplasia with foot malformation.

Visual pattern memory requires foraging function in the central complex of Drosophila.

LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia.

Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23).

Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA.

AFF3 upregulation mediates tamoxifen resistance in breast cancers.

Loss of AR-regulated AFF3 contributes to prostate cancer progression and reduces ferroptosis sensitivity by downregulating ACSL4 based on single-cell sequencing analysis.

AFF3 bioinformatics results - WITH/FROM resolution, donor evidence, ancestry checks, reference projection and automated-route provenance

UniProtKB entry P51826 (AFF3_HUMAN)

Affinage mechanistic annotation for AFF3 (human)