Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
An empirical framework for binary interactome mapping.
Shifted Transversal Design smart-pooling for high coverage interactome mapping.
Next-generation sequencing to generate interactome datasets.
Proteomic characterization of the human sperm nucleus.
A proteome-scale map of the human interactome network.
SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency.
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Biallelic loss-of-function mutations in SLC25A10 abolish DIC protein and its dicarboxylate/phosphate transport activity, causing a severe mitochondrial neurodegenerative disorder (MTDPS19) with complex I deficiency and mtDNA depletion.
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SLC25A10 transports dicarboxylates and phosphate across the inner mitochondrial membrane and is conserved from yeast to mammals; it does not transport glutathione.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans.
A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite Blastocystis.
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Characterizes human SLC25A10 substrate specificity and transporter activity, confirming exchange among dicarboxylates, sulfate, thiosulfate and phosphate.
Human mitochondrial carriers of the SLC25 family function as monomers exchanging substrates with a ping-pong kinetic mechanism.
Sulfide oxidation to sulfate
Sulfate is exported to the cytosol in exchange for dicarboxylate
SLC25A10 mediates exchange of malate and phosphate
SLC-mediated transport of organic anions