Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000041

Gene Ontology annotation based on UniPathway vocabulary mapping

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000111

Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:16326698

BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.

BRCA1 interacts in vivo with the phosphorylated, inactive form of acetyl-CoA carboxylase alpha (P-ACCA) via its BRCT domains and represses lipogenesis by preventing P-ACCA dephosphorylation.

PMID:16794074

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.

TRB3 promotes ubiquitination and degradation of acetyl-CoA carboxylase (ACC) via an association with the E3 ubiquitin ligase COP1, stimulating lipolysis during fasting.

PMID:18056116

Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells.

AKR1B10 associates with acetyl-CoA carboxylase-alpha (ACCA) and stabilizes it; AKR1B10 knockdown increases ACCA degradation via the ubiquitin-proteasome pathway and decreases fatty acid synthesis.

PMID:19343720

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.

Proteomic identification of novel SIRT1/SIRT3 interacting partners; ACACA (ACC1) was curated by IntAct as a SIRT1 interactor from this dataset.

PMID:20457939

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.

MIG12 (MID1IP1) binds ACC and lowers the citrate threshold for polymerization into the physiological range, inducing ACC polymerization and increasing enzymatic activity more than 50-fold; ACC is the first committed enzyme in fatty acid synthesis.

PMID:20952656

Crystal structure of Spot 14, a modulator of fatty acid synthesis.

MIG12 modulates fatty acid synthesis by inducing the polymerization and activity of acetyl-CoA carboxylase; Spot 14 (S14) forms heterodimers with MIG12 that reduce ACC polymerization and activity.

PMID:26976583

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

The allosteric inhibitor ND-630 binds within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization and inhibit the enzymatic activity of both ACC isozymes, reducing fatty acid synthesis and stimulating fatty acid oxidation.

PMID:29899443

Structural basis for regulation of human acetyl-CoA carboxylase.

Cryo-EM structures of human ACC1 reveal activated (citrate-induced) and inhibited (BRCA1 BRCT-bound) filament forms; ACC catalyses the ATP-dependent carboxylation of acetyl-CoA, the rate-limiting step in fatty acid biosynthesis, and ACC1 is the cytosolic isoform (vs mitochondrion-anchored ACC2).

PMID:38892011

Pin1 Exacerbates Non-Alcoholic Fatty Liver Disease by Enhancing Its Activity through Binding to ACC1.

Pin1 interacts directly with ACC1 (its WW domain binding the ACC1 1705-2832 region), inhibits ACC1 phosphorylation and thereby activates it, accelerating fatty acid synthesis and promoting hepatic steatosis in NAFLD.

PMID:7905825

Cloning of human acetyl-CoA carboxylase cDNA.

Cloning and sequencing of human acetyl-CoA carboxylase cDNA; ACC is the rate-limiting enzyme in the biogenesis of long-chain fatty acids.

Reactome:R-HSA-163743

Transcriptional activation of ACACA by ChREBP:MLX

Reactome:R-HSA-1655845

Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1)

Reactome:R-HSA-200555

Formation of Malonyl-CoA from Acetyl-CoA (liver)

Reactome:R-HSA-2993814

HLCS biotinylates ACACA:Mn2+

Reactome:R-HSA-3065958

An unknown protease degrades ACACA

Reactome:R-HSA-3323184

Defective HLCS does not biotinylate ACACA:Mn2+

Reactome:R-HSA-75105

Fatty acyl-CoA biosynthesis

Reactome:R-HSA-75851

Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA