Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans.
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GPR-1/2 bind GDP-Galpha(i/o) via their GoLoco motif, associate with LIN-5 and depend on it for spindle and cortical localization.
"GPR-1/GPR-2 contain a GoLoco/GPR motif that mediates interaction with GDP-bound Galpha(i/o)"
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.
Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo.
LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division.
A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans.
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Uses gpr-1/2 RNAi as a tool to abolish astral pulling forces; corroborates the pulling-force requirement but provides no new GPR-2 function.
"We used a dsRNA that depletes two highly homologous G-protein regulators, GPR-1 and GPR-2, which are required for the production of astral pulling forces"
Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans.
Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning.
A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning.
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.
LET-99 inhibits lateral posterior pulling forces during asymmetric spindle elongation in C. elegans embryos.
Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos.
WormBase gene description for gpr-2 (worm)