An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans.
Evolution of the JAK-STAT pathway.
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The canonical JAK-STAT pathway was assembled in the bilaterian ancestor before protostomes diverged.
"These came together to form the canonical JAK-STAT signaling pathway prior to the divergence of protostomia"
PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription.
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PIAS proteins act as RING-like SUMO E3 ligases.
"proteins promote SUMOylation in a manner that resembles the action of RING-type ubiquitin E3 ligases."
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PIAS interactions and functions extend well beyond STATs.
"PIAS proteins were initially named for their ability to interact with STAT proteins and inhibit their activity, but their interactions and functions are not restricted to the STATs."
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans.
Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos.
The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.
Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans.
A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis.
Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.
Caenorhabditis elegans TBX-2 Directly Regulates Its Own Expression in a Negative Autoregulatory Loop.
A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis.
UniProt entry for C. elegans gei-17 (Q94361)
OpenScientist deep research report for gei-17 (worm)
The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.
Sumoylation regulates protein dynamics during meiotic chromosome segregation in C. elegans oocytes.
PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans.
HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans.
Tissue-specific inhibition of protein sumoylation uncovers diverse SUMO functions during C. elegans vulval development.
piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation.
PIAS1 negatively modulates virus triggered type I IFN signaling by blocking the DNA binding activity of IRF3.
PIAS proteins as repressors of Oct4 function.
OpenScientist focused report on whether GEI-17 keeps the SAP domain and SIMs for ligase-independent repression
GEI-17 acidic-cluster check