PA4379 (warA, Q9HW23) notes

Literature

No deep-research provider was available. PubMed E-utilities returned HTTP 500
on 2026-11-05; the cached publications were searched for WarA/PA4379, and only
PMID:28263305 was found.

WarA was identified as a SadC partner by bacterial two-hybrid screening, and
forms a complex with WarB PMID:28263305.
It binds c-di-GMP by DRaCALA, specifically PMID:28263305.
It is a SAM-dependent methyltransferase with LPS as substrate, stimulated by
c-di-GMP PMID:28263305.
It affects CPA O-antigen modal distribution and immune evasion in zebrafish.

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN008676703	GO:0008168 methyltransferase activity	4	385 (112 taxa)	GO:0008168, IDA, PMID:28263305 (PseudoCAP)	SOUND	Full text read. Purified WarA, SAM donor, LPS acceptor, activity increases with LPS and with c-di-GMP. Generic MTase is the right level because the product is not characterised.	E. coli RlmA P36999 (23S rRNA m1G745 MTase), M. tuberculosis Rv2952 P9WIN3 (PDIM methyltransferase), human TMT1A Q9H8H3 (thiol/N6-adenosine MTase)	Yes. The other seeds are biochemically characterised MTases; the generic term suits a node whose members methylate very different substrates. No defect.

PA4178 (EftM) seeds a different methyltransferase node (PTN000010968), also
SOUND; see genes/PSEAE/PA4178.

Decisions

GO:0005515 protein binding EXP: REMOVE (protein-binding policy).
Methyltransferase (IDA, IBA) and c-di-GMP binding: ACCEPT.