Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases.
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.
Functional dissection of Rab GTPases involved in primary cilium formation.
Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.
Coordination of Rab8 and Rab11 in primary ciliogenesis.
Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration.
Pitchfork regulates primary cilia disassembly and left-right asymmetry.
Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.
Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.
A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.
MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.
Protein LidA from Legionella is a Rab GTPase supereffector.
Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.
OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome.
Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17.
Identification and characterization of multiple novel Rab-myosin Va interactions.
The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.
Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.
Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.
Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11.
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2.
GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.
Multimodal cell maps as a foundation for structural and functional genomics.
RAB3IP stimulates nucleotide exchange on RAB8A
RAB3IP and RAB8A bind to the ciliary targeting complex
RAB3IP stimulates nucleotide exchange on RAB8A
The exocyst complex binds to RAB3IP in the ciliary targeting complex
Cargo-carrying vesicles bud from the TGN
VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane
RGGT geranylgeranylates RAB proteins
RAB8 GEFs exchange GTP for GDP on RAB8
A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport.
CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease.
NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Falcon deep research report for RAB8A