Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns.
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Original cloning of human and mouse CYP8B1; establishes CYP8B1 as a hepatic cytochrome P450 that controls the cholic-acid:chenodeoxycholic-acid ratio in bile, with 12-alpha-hydroxylase enzymatic activity detected on expression in COS cells.
"Sterol 12alpha-hydroxylase (CYP8B1) is a hepatic cytochrome P-450 that controls"
Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1.
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Human CYP8B1 catalyzes 12-alpha-hydroxylation, converting chenodeoxycholate to cholate and the C4 precursor to the cholic-acid intermediate; also identifies CYP8B1 inhibitors.
"The human cytochrome P450 enzyme CYP8B1 is a crucial regulator of the balance of"
CYP8B1 Catalyzes 12alpha-Hydroxylation of C(27) Bile Acid: In Vitro Conversion of Dihydroxycoprostanic Acid into Trihydroxycoprostanic Acid.
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Recombinant and microsomal human CYP8B1 12-alpha-hydroxylate C27 bile-acid intermediates (DHCA to THCA) and C4, with type I heme binding and measured kinetics; reaction phenotyping excludes other P450s.
"both microsomal and recombinant CYP8B1 enzymes catalyze the 12α-hydroxylation of"
CYP8B1 12-hydroxylates 4CHOL7aOLONE
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
CYP8B1 12-hydroxylates 4CHOL7a,27DONE
Sterols are 12-hydroxylated by CYP8B1