Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
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DRAM1 is a p53 target gene encoding a lysosomal protein
"Here we describe DRAM (damage-regulated autophagy modulator), a p53 target gene encoding a lysosomal protein that induces macroautophagy"
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DRAM1 induces macroautophagy
"a p53 target gene encoding a lysosomal protein that induces macroautophagy"
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DRAM1 is essential for p53-mediated apoptosis
"while overexpression of DRAM alone causes minimal cell death, DRAM is essential for p53-mediated apoptosis"
p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death
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p73 also regulates DRAM and autophagy
"TA-p73 also regulates DRAM and autophagy, with different TA-p73 isoforms regulating DRAM and autophagy to varying extents"
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p73 modulation of autophagy is DRAM-independent
"RNAi knockdown of DRAM, however, revealed that p73's modulation of autophagy is DRAM-independent"
Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death
A proteome-scale map of the human interactome network
A reference map of the human binary protein interactome
Deep research summary on DRAM1 function
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DRAM1 promotes ER-lysosome membrane contacts via STIM1
"DRAM1 physically and functionally promotes ER-lysosome contacts via STIM1, disrupting ER structure, triggering ER stress, and inducing ER-phagy"
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DRAM1 stabilizes lysosomal VAMP8
"DRAM1 binds and stabilizes lysosomal VAMP8 by blocking CHIP-mediated ubiquitination (Lys68/72/75)"
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DRAM1 promotes STX17-SNAP29-VAMP8 SNARE complex assembly
"DRAM1 thereby promotes assembly of the STX17-SNAP29-VAMP8 SNARE complex, enhancing autophagosome-lysosome fusion"
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DRAM1 has 6 transmembrane segments with cytosolic C-terminus
"DRAM1 is a conserved, multi-pass lysosomal membrane protein (six transmembrane segments) whose C-terminus faces the cytosol"
DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation
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DRAM1 binds and stabilizes lysosomal VAMP8
"DRAM1 binds and stabilizes lysosomal VAMP8 by blocking CHIP-mediated ubiquitination (Lys68/72/75)"
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DRAM1 promotes STX17-SNAP29-VAMP8 SNARE complex assembly
"DRAM1 directly stabilizes VAMP8, enabling STX17-SNAP29-VAMP8 assembly to drive autolysosome formation"
Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum