XBP1 (human, P17861) review notes

Deep research: not run (falcon times out in this environment; perplexity-lite unavailable).
Review based on cached GOA-cited publications and the UniProt entry.

Key findings

• Spliced XBP1 is the active UPR transcription factor
  PMID:11779464
• bZIP DNA binding/transactivation of CRE-like elements PMID:8657566; c-Fos heterodimer PMID:1903538.
• XBP1u is a negative feedback regulator PMID:16461360, has a type II TMD cleaved by SPP PMID:25239945.
• ATF6-XBP1 heterodimers induce ERAD components PMID:17765680.
• Required for plasma cell differentiation PMID:11460154.

Curation decisions

• Many ISS transfers from mouse (metabolism, development, physiology) kept as non-core.
• bZIP array protein binding -> MODIFY to heterodimerization; identical protein binding -> homodimerization.
• ERAD quality control pathway -> MODIFY to GO:1904294 positive regulation of ERAD pathway.
• positive regulation of T cell differentiation (PMID:11460154, abstract only) -> UNDECIDED.
• NEW: GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific (MF refinement).