Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.
NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.
Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control.
Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1.
Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1.
NEK1 mutations cause short-rib polydactyly syndrome type majewski.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.
The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A central chaperone-like role for 14-3-3 proteins in human cells.
Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.
Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.
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The original study reports NEK1 phosphorylation of RAD54 Ser572 as a mechanism promoting homologous recombination.
"We show that human Nek1 regulates homologous
recombination (HR) by phosphorylating Rad54 at Ser572 in late G2 phase."
Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.
Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis.
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Patient-derived NEK1 variants are associated with primary-ciliary and signaling defects.
"All three NEK1 variants exhibited abnormal
primary ciliary structure, impaired sonic hedgehog signaling, and altered
cell-cycle progression."
Nek1 defines a branch of centriolar microtubule length control parallel to CP110-Cep97.
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NEK1 restricts centriole microtubule elongation in a pathway parallel to CP110-CEP97.
"Loss of Nek1 induces pronounced centriolar
microtubule hyperelongation without displacement of the CP110-Cep97 complex,
indicating that Nek1 restricts centriole extension through a distinct mechanism."
Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis.
Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import.
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NEK1 loss disrupts microtubule homeostasis and nuclear import in human motor-neuron models; alpha-tubulin and importin-beta1 are candidate substrates supported by in vitro phosphorylation assays.
"We
show that α-tubulin and importin-β1, two key proteins involved in these
processes, are phosphorylated by NEK1 in vitro."
Human NEK1 (UniProt Q96PY6): Functional-Annotation Research Report
Focused Primary-Evidence Audit: Human NEK1 (Q96PY6) Uncertain Claims for GO Curation