"Neurons expressing CePPEF include the ciliary chemosensory neurons AWB and AWC"

"[(3)H]Myristate and [(3)H]palmitate labeling studies in 293 cells demonstrated that this association was mediated by myristoylation at Gly(2) and palmitoylation at Cys(3)"

"Neurons expressing CePPEF include the ciliary chemosensory neurons AWB and AWC; and within these neurons, CePPEF is highly enriched in the sensory cilia"

"A recombinant C-terminal fragment of CePPEF containing two putative EF-hands bound between one and two Ca(2+) ions/protein"

"Introducing the G2A or C3S mutation into CePPEF greatly reduced membrane association in 293 cells and in transgenic nematodes"

"we found the PEF-1::GFP protein to be concentrated within the cilium, but in a region distal to the transition zone (TZ), which represents the proximal-most region of the axoneme"

"We find that disrupting the scaffolding proteins MKS-5 or CEP-290 causes PEF-1::GFP mislocalization, diminishing its enrichment within the ciliary region distal to the TZ"

"We generated a strain bearing a PEF-1::GFP fusion protein construct under the control of the endogenous pef-1 promoter and observed expression in several head-localized ciliated neurons, including AFD, AWC, ASE, BAG, and PQR, as well as the tail-localized ciliated neurons PHA and PHB"

"our findings suggest that C. elegans PEF-1 plays roles in ciliated sensory neurons that control various sensory modalities and regulate behaviors, including chemosensation, thermosensation, and to a lesser degree, photosensation"

"the pef-1 null mutant behaves like wild-type (i.e., shows an avoidance phenotype) when confronted with a high-osmolarity glycerol barrier"

"While this ciliary subdomain (distal segment) is indeed present and bounded by a membrane, the singlet microtubules which are readily identified in wild-type cilia70 are absent or indistinct in the pef-1 mutant"

"PPEF proteins have not been specifically associated with a ciliary function in any organism"