Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting.
The protein network of HIV budding.
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.
Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting.
Towards a proteome-scale map of the human protein-protein interaction network.
Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1.
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway.
HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions.
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
CHMP4B, a novel gene for autosomal dominant cataracts linked to chromosome 20q.
The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.
Plasma membrane deformation by circular arrays of ESCRT-III protein filaments.
The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis.
ALIX-CHMP4 interactions in the human ESCRT pathway.
Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Membrane scission by the ESCRT-III complex.
A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments.
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Membrane budding and scission by the ESCRT machinery: it's all in the neck.
Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.
The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes.
Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments.
Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.
The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release.
ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons.
Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding.
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C.
Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B.
ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting.
The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis.
ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation.
ESCRT requirements for EIAV budding.
ESCRT machinery is required for plasma membrane repair.
Structure of cellular ESCRT-III spirals and their relationship to HIV budding.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.
ESCRT-III controls nuclear envelope reformation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery.
The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission.
Recruitment Of HIV Virion Budding Machinery
VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites
Local curation notes for CHMP4B
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Local synthesis identifies CHMP4B/Snf7-2 ESCRT-III polymerization, membrane bending, and MVB/endolysosomal sorting as core functions, with autophagy and other ESCRT outputs retained in context.
Falcon deep research report for CHMP4B