Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
A reference map of the human binary protein interactome.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Cryo-EM structure of the human IgM B cell receptor.
Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression.
Immunoglobulin M perception by FcμR.
Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
CD22 binds B-cell receptor
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
The Immunoglobulin of the BCR binds antigen
SYK binds the activated BCR
p-6Y-SYK phosphorylates BLNK (SLP65)
SYK autophosphorylates at the activated BCR
Cutting edge: a hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development.
B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.
Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex.
B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta.
Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation.
Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor.
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Purified human and murine Ig-beta extracellular domains form disulfide-bonded homodimers; this biochemical property does not replace the physiological Ig-alpha/Ig-beta BCR signaling heterodimer.
"the extracellular domains of murine and
human Igbeta form an I-set immunoglobulin-like structure with an interchain
disulfide between cysteines on their G strands."