Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Isolation and characterisation of a novel stress-inducible PDI-family gene from Aspergillus niger.
Functional analysis of tunicamycin-inducible gene A polypeptide from Aspergillus niger.
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TigA has PDI isomerase activity (refolding RNase A)
"TIGA acted as an isomerase, catalyzing the refolding of denatured and reduced ribonuclease A."
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TigA has chaperone activity (refolding prochymosin but not GAPDH)
"TIGA also exhibited chaperone activity in the refolding of denatured prochymosin but not in the refolding of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), indicating that it had substrate specificity with respect to chaperone activity."
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N-terminal thioredoxin motif is more active than C-terminal
"The N-terminal trx-motif was more active than the C-terminal trx-motif"
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First cysteine in each CXXC motif is necessary for isomerase activity
"the first cysteine in each trx-motif was necessary for isomerase activity."
Deep research report on tigA (Falcon/Edison Scientific Literature)