EPT1 (YHR123W, P22140) notes

Identity

• sn-1,2-diacylglycerol ethanolaminephosphotransferase, EC 2.7.8.1 (also 2.7.8.2 in vitro); CDP-alcohol phosphatidyltransferase family; multi-pass membrane protein [UniProt:P22140].

Evidence

• Distinct CPT1/EPT1 enzymes; double null lacks both activities but is viable PMID:1847919
• Broad aminoalcohol specificity PMID:1847919.
• ept1 mutants lose most EPT activity; overexpression raises it PMID:2848840; dual activity PMID:2848840.
• UniProt: does not substantially contribute to PC synthesis in vivo [UniProt:P22140].
• Localization: Golgi (GFP, PMID:14562095), ER (PMID:26928762 HDA).

Curation decisions

• Core: GO:0004307 + PE biosynthesis; cholinephosphotransferase/PC rows non-core.
• Cytosol RCA rows removed (integral membrane protein).
• protein binding (Ept1-Cpt1 paralog interaction, three HTP/interactome papers) removed per policy.