Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Inactivation of mitogen-activated protein kinases by a mammalian tyrosine-specific phosphatase, PTPBR7.
Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm.
Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.
c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.
Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1.
Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase.
Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence.
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.
Erk phosphorylates threonine 42 residue of ribosomal protein S3.
The tyrosine kinase Syk regulates TPL2 activation signals.
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress.
MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling.
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction.
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Regulation of human myoblast differentiation by PEBP4.
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).
The ERK signaling cascade--views from different subcellular compartments.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2.
Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.
DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs.
A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2.
The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction.
High-throughput RNAi screening reveals novel regulators of telomerase.
A directed protein interaction network for investigating intracellular signal transduction.
PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus.
HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms.
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.
Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus.
The protein interaction landscape of the human CMGC kinase group.
SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells.
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway.
Phosphorylation of myofibrillogenesis regulator-1 activates the MAPK signaling pathway and induces proliferation and migration in human breast cancer MCF7 cells.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis.
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.
Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells.
N(6) -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma.
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
MAP2K1 phosphorylates MAPK3
Dissociation of p-T,Y-MAPK3:MAP2K1
ISGylation of host proteins
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
ERK1/2/5 activate RSK1/2/3
ERK1/2 phosphorylates MSK1
ERKs are inactivated by protein phosphatase 2A
p-ERK phosphorylates WAVEs and ABI
ERKs are inactivated by dual-specific phosphatases (DUSPs)
MAPKs phosphorylate ETS1 and ETS2
Constitutive phosphorylation by pERK1/2
MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)
F2R:ARRB1 binds MAPKs, SRC-1
F2R:ARRB2 binds MAPKs, SRC-1
SRC-1 bound to ARRB2 is not activated
c-FOS activation by phospho ERK1/2
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
MAP2Ks and MAPKs bind to the activated RAF complex
MAP2Ks phosphorylate MAPKs
RAF phosphorylates MAP2K dimer
Dissociation of RAS:RAF complex
MAP2Ks and MAPKs are phosphorylated at the endosome membrane
WDR83:LAMTOR2:LAMTOR3 binds MAPK components
IL17RD binds p-2S MAP2Ks and MAPKs
MAP2Ks phosphorylate MAPK at the Golgi membrane
Phosphorylated MAPKs translocate into the nucleus
Activated MAPKs phosphorylate MAP2K1
Activated MAPK phosphorylates RAF1
Activated MAPKs phosphorylate BRAF
PEA15 binds MAPK monomers and dimers
Nuclear DUSPs dephosphorylate MAPKs
Cytosolic DUSPs dephosphorylate MAPKs
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants
High kinase activity BRAF complexes phosphorylate MAP2Ks
High kinase activity BRAF mutants bind MAP2Ks and MAPKs
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks
Dissociation of BRAF/RAF fusion complex
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks
Dissociation of high activity BRAF complexes
Dissociation of moderate activity BRAF complexes
Dissociation of oncogenic RAS:RAF complex
Dissociation of paradoxically activated RAS:BRAF complexes
IER3 recruits MAPKs to PP2A-B56-beta,gamma
Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
Activated BRAF recruits MAP2Ks and MAPKs to the endosome
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
Dissociation of phosphorylated MAP2Ks and MAPKs
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
p-T,Y MAPK dimers translocate to nucleus
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345
CASP9 is phosphorylated at T412
PTPN7 dephosphorylates p-T,Y-MAPKs
MAP2K mutants constitutively phosphorylate MAPKs
Dissociation of RAS:RAF1 mutant complex
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants
RAF1 mutant complexes phosphorylate MAP2K dimer
Dual mechanism MAP2K inhibitors bind MAP2Ks
Dual mechanism MAPK inhibitors bind MAPKs
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
Single mechanism MAPK inhibitors bind phosphorylated MAPK
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3
JAK1-activated RAF1 phosphorylates MAPKs
JAK2-activated MAPKs phosphorylate YBX1
ERKs phosphorylate MCRIP1
MAPK-dependent phosphorylation of KARS
CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation
UniProtKB P27361 (MAPK3_HUMAN) entry
Deep research report on human MAPK3 (Falcon)