Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
The dual roles of AlgG in C-5-epimerization and secretion of alginate polymers in Pseudomonas aeruginosa.
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AlgG deletion exposes nascent polymer to AlgL degradation, whereas the S272N allele loses epimerization but retains polymer protection/export.
"AlgG is bifunctional with (i) epimerase activity and (ii) a role in protecting alginate from degradation by AlgL during transport through the periplasm."
Pseudomonas aeruginosa AlgG is a polymer level alginate C5-mannuronan epimerase.
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AlgG is processed into a mature periplasmic protein and directly epimerizes polymeric mannuronate into guluronate.
"These results demonstrate that AlgG has polymer-level mannuronan C5-epimerase activity."
Pseudomonas aeruginosa C5-mannuronan epimerase: steady-state kinetics and characterization of the product.
Chemical mechanism and specificity of the C5-mannuronan epimerase reaction.