GRX2 (YDR513W, UniProt P17695) notes

• Dithiol CPYC glutaredoxin; major heat-stable glutaredoxin activity: "the grx2 mutant displayed only 20% of the wild-type activity, indicating that Grx2 accounted for the majority of this activity in vivo" PMID:9571241; grx2 is H2O2 sensitive PMID:9571241.
• Recombinant Grx2 "efficiently catalyses the reduction of hydroxyethyl disulphide by GSH" and "also catalyses the reduction of GSSG by dihydrolipoamide" PMID:11958675.
• Two isoforms from alternative in-frame AUGs: "Translation from the first AUG resulted in a long isoform carrying a mitochondrial targeting presequence" and the "cytosolic isoform of Grx2 was synthesized from the second AUG" PMID:16606613; unprocessed form accumulates in the mitochondrial outer membrane PMID:16606613.
• Peroxidase/GST: "Grx2 is also a general hydroperoxidase"; "both Grx1 and Grx2 are shown be active as glutathione S-transferases" PMID:12684511.
• Backup GSSG reduction in cytosol: "we identify Trx2 and Grx2 as efficient backup systems to glutathione reductase for cytosolic GSSG reduction" PMID:23242256.
• Mitochondrial proteomics hits: PMID:14576278, PMID:16823961, PMID:24769239.

Module

• glutathione_thioredoxin_redox_systems: exemplar for GO:0015038 (cytosol). Note the mitochondrial isoform; the module should note dual localization (cytosol + mitochondrial matrix).