Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium.
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CAR4 is a cell-surface, G protein-linked cAMP receptor.
"the gene for a new cell-surface, G protein-linked cAMP receptor"
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CAR4 is maximally expressed in the prestalk-rich anterior of the pseudoplasmodium, a center for extracellular cAMP signaling and patterning.
"CAR4 is maximally expressed in pseudoplasmodia anteriors which are centers for extracellular cAMP signaling and for organization of cellular patterning"
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car4 nulls progress through early development but show major anteroposterior patterning defects during late development.
"Although car4 null cells progress unperturbed through early development, they exhibit major patterning aberrations as the anteroposterior axis becomes established"
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CAR4 promotes prestalk gene expression and restricts prespore differentiation to the appropriate spatial domain.
"Prestalk gene expression is significantly reduced in car4 nulls, whereas prespore-specific markers are overexpressed and detected in zones normally restricted to prestalk cells"
The cyclic nucleotide specificity of eight cAMP-binding proteins in Dictyostelium discoideum is correlated into three groups.
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The Dictyostelium cell-surface cAMP receptors bind cAMP in a hydrophobic cleft and transduce the cAMP signal during chemotaxis and differentiation.
"cAMP is probably bound to the surface receptors in the anti conformation in a hydrophobic cleft of the receptor"
Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice.
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CAR4 regulates a protein tyrosine phosphatase that inhibits GSK3 activity, controlling cell-fate choice in a manner paralleling Wnt/Frizzled-GSK3 signaling.
"We now show that CAR4 regulates a tyrosine phosphatase that inhibits GSK3 activity"
Chemoattractant signaling in dictyostelium discoideum.
Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium.
Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.
Switching of chemoattractant receptors programs development and morphogenesis in Dictyostelium: receptor subtypes activate common responses at different agonist concentrations.
OpenScientist assessment of CAR4 adenylate-cyclase-activating signaling