Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein.
A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways.
The life and death of oligodendrocytes in vanishing white matter disease.
An efficient mammalian cell-free translation system supplemented with translation factors.
A proteome-scale map of the human interactome network.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3.
A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B.
Formation of eIF2:GDP:eIF2B intermediate
Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Identification of ten novel mutations in patients with eIF2B-related disorders.
The finished DNA sequence of human chromosome 12.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Initial characterization of the human central proteome.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Structural basis for eIF2B inhibition in integrated stress response.
Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells.
Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans.
Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats.
EIF2B1 evidence reconstruction
EIF2B1 source and assay guide